![]() ![]() On the other hand, in DC, HA obtained from Dystric Cambisol, no significant relationships were observed between each type of protons and aromatic protons. These results suggest that the increase in HA particle sizes depends on the length of aliphatic groups and the bond of methoxyl groups, and HAs were composed of HA molecules of homologous series. In addition, with increasing particle size, the percentage of aromatic protons decreased. ![]() Such a negative linear correlation was also observed between Har and Hbeta. Based on the 1H NMR data in UA, there was a significantly negative linear correlation between Har and Hco. dveloppements de la spectroscopie RMN en 1 et 2 Auler JO, Atik E, baid M. Deux scientifiques de lquipe MIMM du laboratoire. With increasing particle sizes, the absorption of methylene groups and amide of peptides increased in the IR spectra of both HAs and that of carboxylic groups decreased in the IR spectra of UA, the HA obtained from an Umbric Andosol. Un nouveau livre sur la spectroscopie RMN 2D dit par des scientifiques du CEISAM 9 juin 2023 9 juin 2023. However more information can be obtained using variable field NMR relaxometry.Humic acids (HAs) extracted from an Umbric Andosol (UA) and a Dystric Cambisol (DC) wee fractionated into 7 fractions by successive gel permeation chromatography (GPC) and their fractions were studied by spectral analysis. La spectroscopie par Rsonance Magntique Nuclaire, ou RMN, permet d’obtenir des informations sur la structure de la chaine carboned’une molcule, en particulier sur les atomes d’hydrogne(appels protons) ports par celle-ci. Low field proton relaxometry, with water as probe molecule, is efficient to probe the porosity of porous polymer particles. Now, we want to push the limits of our methods in order to be able to follow in situ and at the atomic scale the processes occurring during drug delivery from a MOF in a biological medium.Įvolution of the MOF NP porosity during drug delivery is also a parameter to take into account. The NMR methods are nowadays well established for the study of host-guest interactions in porous solids. Analysis of solid-state NMR spectra provides information about the nature and quantity of the species, their coordination, dynamics and potential interactions. Nuclear magnetic resonance is among the most powerful spectroscopic techniques in use today. ![]() In this context, nuclear magnetic resonance (NMR), a non-destructive local technique, appears ideally suited to study these MOF NPs that lack long-range order. If usual techniques (HPLC, etc) can provide data on the delivery, none of them allows an accurate description at the atomic scale of the nanoMOF and active principle ingredient evolution during degradation, the nature of the formed species and their influence upon drug release. The control over the MOF NP degradation in biological media is a key parameter as it in turn allows a better control of the drug delivery kinetics. The PMR spectroscopic properties (250 MHz) for cycloadducts of diphenylnitrilimine towards 1,2-dihydronaphthalenes substituted at the C 1 -carbon atom have. Programeaza-te pentru investigatie Prenume Sunt de acord sa primesc e-mailuri despre noutati si oferte personalizate. The high porosity of MOFs, their high specific surface and unrivalled versatility in terms of composition and easy functionalization, are the reasons why these materials are particularly appealing systems for loading of large amounts of therapeutic molecules. Afla mai multe despre imagistica prin Rezonanta Magnetica (IRM) sau Rezonanta Magnetica Nucleara (RMN), tehnologiea imagistica moderna care ofera un diagnostic precis, fara radiatii. Nanoparticles (NPs) based on porous metal-organic frameworks (MOFs) are of growing interest in medicine, with applications for controlled drug delivery, targeting of diseased tissues/organs or in imaging. Nuclear Magnetic Resonance Spectroscopy (NMR) is an analytical technique that can reveal structural information about many organic and inorganic molecules. Project leader: Charlotte Martineau-Corcos ![]()
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